What is the Origin of Sustained Lean Mass Accrual?

The concept is a key goal in sports science, clinical nutrition, and sarcopenia research, emphasizing the durability and persistence of muscle growth over time. The term "accrual" suggests a steady, cumulative process rather than an acute, short-lived response. This objective is the focus of therapeutic interventions against age-related muscle loss.

What is the Mechanism of Sustained Lean Mass Accrual?

Sustained accrual requires a persistent positive net protein balance, meaning protein synthesis must consistently exceed protein degradation. The mechanism is supported by chronic optimization of anabolic hormones, such as insulin and testosterone, alongside consistent mechanical tension from resistance training. This environment promotes satellite cell activation and the long-term incorporation of new myofibrillar proteins into existing muscle fibers, leading to measurable hypertrophy.

Sustained Lean Mass Accrual ∞ Area

Sustained Lean Mass Accrual

Meaning

Sustained lean mass accrual describes the long-term, continuous, and measurable increase in fat-free body mass, primarily skeletal muscle, achieved through a consistent regimen of training, nutrition, and optimized hormonal signaling. This process moves beyond temporary muscle gain to establish a new, higher baseline of tissue anabolism and maintenance. It is a critical outcome for improving metabolic health, functional strength, a key component of longevity, particularly in aging populations. The accrual reflects a fundamental shift in systemic anabolic drive.