What is the Origin of Sustained Healthspan Extension?

This term is a core concept in geroscience, evolving from the distinction between lifespan (total years lived) and healthspan (years lived in good health). The addition of 'sustained' emphasizes that the extension must be maintained through ongoing, proactive, and adaptive clinical management. The foundation is rooted in the biological understanding of the hallmarks of aging.

What is the Mechanism of Sustained Healthspan Extension?

The mechanism involves implementing long-term, personalized strategies to slow the rate of biological aging, often measured by epigenetic clocks and telomere length. Key pathways targeted include nutrient sensing (mTOR, AMPK), mitochondrial biogenesis, and chronic inflammation control. Hormonal balance, particularly the appropriate management of growth hormone, thyroid, and sex steroids, is utilized to maintain youthful cellular and systemic function, thereby extending the period of robust health.

Sustained Healthspan Extension

Meaning

Sustained Healthspan Extension is the clinical and biological goal of increasing the number of years an individual lives in good health, free from chronic disease and functional impairment, rather than merely extending total lifespan. This comprehensive objective requires continuous physiological optimization across all major organ systems, focusing on maintaining vitality, cognitive function, and metabolic resilience well into later life. It represents the pinnacle of longevity medicine.