What is the Origin of Sustained GH Release?

This concept is a refinement of growth hormone replacement therapy, recognizing that the pulsatile nature of endogenous GH secretion is essential for its beneficial effects on body composition and metabolism. Clinical research demonstrated that non-pulsatile or overly high-peak administration can lead to desensitization or side effects. The focus shifted to using secretagogues that promote the body's own rhythmic release.

What is the Mechanism of Sustained GH Release?

Sustained GH release is typically achieved using Growth Hormone-Releasing Hormone (GHRH) analogs or Growth Hormone Secretagogues (GHS) that have a prolonged half-life or are administered in a manner that maintains receptor saturation over time. These agents act on the pituitary gland to stimulate the continuous yet modulated release of GH into the bloodstream. This consistent presence of GH ensures stable downstream production of Insulin-like Growth Factor 1 (IGF-1) in the liver, driving continuous protein synthesis, lipolysis, and tissue repair without causing undue physiological stress.

Sustained GH Release

Meaning

The therapeutic objective of achieving a continuous, physiologically relevant pattern of Growth Hormone (GH) secretion that avoids the rapid, supra-physiological peaks and troughs associated with conventional replacement methods. This sustained release mimics the natural, pulsatile pattern of a youthful somatotropin axis, ensuring consistent signaling to target tissues. It is the optimal method for leveraging GH’s anabolic and metabolic benefits for long-term health and tissue maintenance.