The consistent, reliable level of whole-body energy availability maintained over extended periods, reflecting stable mitochondrial output and efficient substrate utilization across major organ systems, independent of acute nutritional intake or short-term stressors. This baseline supports anabolic processes, cognitive function, and immune surveillance without periods of significant fatigue or metabolic crash. It is the foundation of physiological resilience.
Origin
This concept is drawn from bioenergetics and applied endocrinology, emphasizing that long-term vitality depends not on peak energy bursts but on a high, steady foundational level of ATP production. Hormones like thyroid hormone and insulin play pivotal roles in setting this baseline.
Mechanism
Sustaining this baseline requires balanced regulation of the thyroid axis for basal metabolic rate control and consistent insulin signaling to ensure tissues have constant access to usable fuel sources. Furthermore, optimizing cellular longevity markers reduces the metabolic drag imposed by accumulating cellular damage, thereby freeing up energy resources for maintenance and high-level function.
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