What is the Origin of Sustained Elevated Baseline?

The term is derived from stress physiology and endocrinology, specifically relating to the concept of allostasis and the long-term effects of chronic stress. A sustained elevated baseline contrasts sharply with the healthy, transient elevations seen during acute stress or the Cortisol Awakening Response. This persistent signal fatigues receptor sites and drives catabolic processes.

What is the Mechanism of Sustained Elevated Baseline?

The sustained high concentration of a hormone, such as cortisol, leads to downregulation of its receptors in target tissues, contributing to functional resistance and metabolic derangement. Chronically elevated levels promote gluconeogenesis, impair immune function, and suppress the production of anabolic hormones like testosterone and growth hormone. The lack of a true rest period prevents the body from executing necessary repair and restoration cycles.

Sustained Elevated Baseline ∞ Area

Sustained Elevated Baseline

Meaning

This describes a pathological state where a physiological marker, often a stress hormone like cortisol or an inflammatory cytokine, remains persistently above its healthy, resting diurnal nadir for an extended period. This chronic elevation signifies an inability of the body to return to a state of homeostasis, indicating significant allostatic load or HPA axis dysregulation. It is a critical risk factor for metabolic and cardiovascular disease.