Sustained cognitive homeostasis refers to the long-term maintenance of optimal brain function, characterized by stable executive function, emotional regulation, and resistance to neurodegenerative processes, achieved through the continuous support of the neuro-hormonal and metabolic environment. This state is not merely a temporary boost but a robust, enduring physiological balance where the brain’s energy metabolism, neurotransmitter synthesis, and cellular repair mechanisms operate efficiently. Achieving this sustained balance is critical for long-term healthspan and is profoundly influenced by the integrity of the endocrine system.
Origin
This term integrates concepts from neurobiology, endocrinology, and gerontology, extending the general principle of homeostasis to the specific and complex functions of the brain. The term ‘sustained’ emphasizes the therapeutic goal of creating a resilient, enduring state of optimal cognitive function, moving beyond short-term symptomatic relief.
Mechanism
Maintenance is achieved by ensuring a constant, adequate supply of energy to neurons, primarily through stable glucose metabolism and mitochondrial efficiency, both of which are regulated by hormones like insulin and thyroid hormone. Furthermore, it requires the continuous, balanced neurotrophic support provided by hormones like BDNF and sex steroids, which protect synapses and promote neuroplasticity. The endocrine system’s precise regulation of inflammation and oxidative stress within the central nervous system is also paramount to preventing the degradation that undermines cognitive stability.
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