A structured, multi-faceted clinical regimen designed to continuously promote the net synthesis of complex biomolecules, particularly muscle protein and bone matrix, over their breakdown (catabolism), thereby driving long-term tissue growth and repair. This protocol integrates precise nutritional timing, resistance training, and targeted hormonal or peptide support to maintain a positive nitrogen balance and counter the age-related decline in muscle mass, known as sarcopenia.
Origin
This term is a clinical and fitness-oriented phrase derived from the biochemical concept of “anabolism,” the constructive part of metabolism, combined with “sustained” to denote a continuous state, and “protocol” to indicate a structured plan. It is central to anti-aging and performance medicine.
Mechanism
The protocol’s core mechanism relies on maximizing the sensitivity and availability of key anabolic signaling pathways, such as the Insulin-like Growth Factor 1 (IGF-1)/mTOR pathway. Strategic administration of growth hormone, testosterone, or their secretagogues enhances muscle protein synthesis and reduces protein degradation. Furthermore, a consistent supply of essential amino acids and energy substrates, coupled with regular mechanical tension from exercise, provides the necessary raw materials and stimuli to maintain this constructive metabolic state.
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