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SUSTAIN Trial

Meaning

The SUSTAIN Trial program refers to a comprehensive series of large-scale, international, randomized controlled clinical trials specifically designed to evaluate the efficacy and cardiovascular safety of semaglutide, a glucagon-like peptide-1 receptor agonist, in patients with type 2 diabetes. These landmark trials provided robust, high-level evidence demonstrating the drug’s capacity to achieve significant improvements in glycemic control, promote sustained weight reduction, and importantly, reduce the risk of major adverse cardiovascular events. The findings have profoundly influenced global endocrine clinical practice guidelines.