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SURPASS-4 Trial

Meaning

The SURPASS-4 Trial was a pivotal, large-scale, randomized controlled clinical trial designed to evaluate the efficacy and cardiovascular safety of the novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, tirzepatide, in patients with Type 2 diabetes who had established cardiovascular disease or were at high cardiovascular risk. This trial provided critical evidence regarding the drug’s profound glucose-lowering and weight-loss effects, alongside its demonstrated reduction in cardiovascular events. The results significantly influenced the clinical management guidelines for diabetes and hormonal-metabolic health.