Surgical Menopause Intervention refers to the abrupt cessation of ovarian hormone production caused by the bilateral surgical removal of the ovaries, known as a bilateral oophorectomy. This procedure induces an immediate and complete hormonal deficiency, often resulting in severe and sudden menopausal symptoms and a heightened risk for long-term health issues compared to natural menopause. Clinical management requires immediate and often aggressive hormone replacement therapy to mitigate the profound physiological shock.
Origin
The term is a clinical descriptor for the iatrogenic (medically induced) form of menopause, distinct from the gradual, natural process. While the procedure is sometimes necessary for gynecological pathology, the intervention highlights the immediate, non-gradual nature of the hormonal decline. The clinical challenge lies in addressing the sudden loss of not only estrogen and progesterone but also ovarian androgens.
Mechanism
The removal of the ovaries eliminates the primary source of sex steroid synthesis, causing a rapid decline in circulating estrogen, progesterone, and testosterone. This abrupt withdrawal triggers immediate vasomotor symptoms and accelerates bone loss and cardiovascular risk due to the sudden loss of hormonal protection. The intervention necessitates a therapeutic mechanism that involves the exogenous administration of bioidentical hormones to mimic the protective effects that were suddenly lost.
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