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Supratherapeutic Levels

Meaning

Concentrations of a drug, hormone, or metabolite in the circulation that exceed the established upper limit of the therapeutic reference range, potentially increasing the risk of adverse side effects or toxicity without conferring additional clinical benefit. In the hormonal health context, this refers to hormone levels that are significantly higher than those required for optimal physiological function or symptomatic relief. These levels often result from inappropriate dosing or impaired metabolic clearance.