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Supraphysiological State

Meaning

A Supraphysiological State refers to a condition within the body where the concentration of a specific hormone or physiological substance significantly exceeds the levels naturally produced or maintained under normal, healthy conditions. This state is often induced intentionally through the exogenous administration of high-dose hormones, such as in certain pharmacological treatments or in the context of performance enhancement. While sometimes necessary for specific clinical outcomes, maintaining a supraphysiological state carries an inherent risk of activating unintended signaling pathways, causing receptor down-regulation, or inducing adverse side effects that disrupt normal endocrine homeostasis.