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Supraphysiological Range

Meaning

The Supraphysiological Range defines a concentration of an endogenous substance, such as a hormone or metabolite, that significantly exceeds the highest levels typically observed in a healthy, non-pathological state for a given age and sex. While often used in the context of pharmacological intervention, particularly in performance enhancement, maintaining levels within this range can induce both profound therapeutic benefits and significant risks, including the disruption of normal endocrine feedback loops and adverse effects on cardiovascular health. Clinical monitoring is essential when levels transiently or chronically enter this concentration domain.