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Supraphysiological Dosing

Meaning

Supraphysiological Dosing refers to the clinical administration of a therapeutic agent, typically a hormone or a hormone analog, at a concentration that significantly exceeds the levels naturally produced by the body under normal, healthy, and homeostatic conditions. This dosing strategy is fundamentally distinct from standard replacement therapy, which merely aims to restore levels to a normal physiological range. It is employed therapeutically to achieve a specific, often potent, pharmacological effect that is not attainable with standard doses, requiring careful clinical monitoring due to the potential for heightened side effects.