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Supraphysiological Doses

Meaning

Supraphysiological doses are defined as the administration of an exogenous substance, such as a hormone or peptide, at concentrations that exceed the maximal range naturally produced or maintained by the body under normal, healthy conditions. In clinical practice, the use of these doses is a critical consideration, as they are often employed for specific pharmacological effects that require receptor saturation or pathway override, but they carry an increased risk of side effects and disruption of the body’s natural endocrine feedback loops. Responsible clinical translation requires precise justification and intensive monitoring when utilizing dosages that exceed established physiological norms.