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Supraphysiological Avoidance

Meaning

Supraphysiological avoidance is the clinical strategy of intentionally preventing the concentration of administered hormones or therapeutic agents from exceeding the highest levels naturally observed in a healthy, young adult human body. This principle is fundamental to ethical and safe hormone optimization, ensuring that interventions, such as testosterone or thyroid hormone replacement, mimic youthful endocrine function without inducing pharmacological excess. The goal is to restore optimal physiological function and mitigate the systemic risks associated with unnaturally high hormonal exposure.