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SULT1B1

Meaning

SULT1B1, or Sulfotransferase Family 1B Member 1, is a cytosolic enzyme responsible for catalyzing the sulfation of a diverse range of small molecules, including hormones, neurotransmitters, and xenobiotic compounds. In the context of hormonal health, SULT1B1 plays a significant role as a major thyroid hormone sulfotransferase, specifically inactivating triiodothyronine (T3) and thyroxine (T4) by converting them into inactive sulfate esters. This process is a crucial step in the metabolic clearance and detoxification of these active compounds.