Question 1

What is the Meaning of SULT1A1 Enzyme?

Accepted Answer

SULT1A1, or Sulfotransferase Family 1A Member 1, is a key phase II detoxification enzyme. It catalyzes the transfer of a sulfonate group from 3'-phosphoadenosine-5'-phosphosulfate to various endogenous and exogenous compounds. This enzymatic action is fundamental for metabolic processing and elimination.

Question 2

What is the Context of SULT1A1 Enzyme?

Accepted Answer

This enzyme is widely distributed, with significant expression in the liver, small intestine, and steroidogenic tissues. SULT1A1 participates in the sulfation of a broad spectrum of substrates, including steroid hormones like estrogens and DHEA, thyroid hormones, and numerous xenobiotics. Its activity is integral to maintaining hormonal homeostasis and facilitating chemical clearance.

Question 3

What is the Significance of SULT1A1 Enzyme?

Accepted Answer

Variations in SULT1A1 activity directly influence an individual's capacity to metabolize certain medications and endogenous hormones. Clinical outcomes can be affected, from altered drug efficacy to increased adverse reactions. Understanding SULT1A1 function provides insight into individual differences in hormonal regulation and detoxification, relevant in personalized health management.

Question 4

What is the Mechanism of SULT1A1 Enzyme?

Accepted Answer

SULT1A1 performs a sulfoconjugation reaction, which typically increases the water solubility of its substrates. This modification renders compounds more amenable to excretion via renal or biliary routes. For many hormones, sulfation by SULT1A1 leads to their deactivation, serving as a critical regulatory step in hormonal signaling. It can also modulate compound activity.

Question 5

What is the Application of SULT1A1 Enzyme?

Accepted Answer

Clinical consideration of SULT1A1 is increasingly important in pharmacogenomics, guiding medication selection and dosing strategies. Its role in hormone metabolism informs approaches to hormonal health, particularly when assessing estrogen or thyroid balance. For individuals with compromised detoxification, evaluating SULT1A1 activity can help tailor interventions.

Question 6

What is the Metric of SULT1A1 Enzyme?

Accepted Answer

While direct clinical measurement of SULT1A1 enzyme activity is not routinely available, genetic polymorphisms within the SULT1A1 gene, such as the common SULT1A12 allele, are identified through genetic testing. These genetic markers can predict an individual's likely sulfation capacity. Indirect assessments may involve evaluating metabolite profiles in urine.

Question 7

What is the Risk of SULT1A1 Enzyme?

Accepted Answer

Individuals with genetically reduced SULT1A1 activity may be at higher risk for adverse drug reactions from medications primarily cleared by this enzyme. Impaired sulfation can also lead to the accumulation of certain unconjugated hormones or toxins, potentially contributing to endocrine disruption or increased physiological burden. Dietary compounds can inhibit SULT1A1, compromising metabolic clearance.

SULT1A1 Enzyme

Meaning

Context

Significance

Mechanism

Application

Metric

Risk

How Do Genetic Variations Influence Individual Responses to Minoxidil and Finasteride?

Can Genetic Testing Accurately Predict Individual Responses to All Hair Loss Treatments?

Provided by the clinical team
at 4Ever Young Miami Dadeland

-15% ∞ HRTIO15

Your protocol begins with a conversation.

Visit

Schedule Appointment

About

Med & Wellness

4Ever Young Miami Dadeland

Communication

+1 786-529-6686

Email Us

Opening Hours