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Sulfated Metabolite Concentration

Meaning

Sulfated Metabolite Concentration refers to the measurable level of specific steroid hormones or other biological compounds that have undergone a sulfation reaction, a critical Phase II detoxification process in the liver and other tissues. This process, which attaches a sulfate group to the molecule, typically renders the compound inactive, water-soluble, and ready for excretion via the urine. Clinically, the concentration of these sulfated forms, such as DHEA-S or sulfated estrogen metabolites, provides vital information about both hormone production and the efficiency of the body’s detoxification and elimination pathways. Low sulfation capacity can lead to the recirculation of potentially harmful, non-excreted compounds.