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Substrate Utilization Timing

Meaning

Substrate Utilization Timing is the precise, chronobiological regulation of when the body shifts its primary energy source between macronutrients, such as carbohydrates, fats, and proteins, in alignment with circadian rhythm, activity levels, and nutrient availability. Optimizing this timing is essential for metabolic flexibility, which is the capacity to efficiently switch fuel sources, and is a key strategy for managing insulin sensitivity and body composition. Disruptions in this timing can lead to metabolic rigidity and contribute to chronic disease, impairing overall energy efficiency.