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Substrate Utilization Metrics

Meaning

Substrate Utilization Metrics quantify the relative proportions of glucose versus fatty acids being oxidized by the body for energy production at a given time point or over a defined period. These metrics, often derived from indirect calorimetry or stable isotope tracers, reveal the body’s metabolic flexibility, a cornerstone of endocrine health. Poor utilization metrics, such as an inability to efficiently burn fat at rest, correlate strongly with insulin resistance and metabolic syndrome. Analyzing these ratios provides insight into mitochondrial efficiency and hormonal control over fuel selection.