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Substrate Replacement Therapy

Meaning

Substrate Replacement Therapy is a targeted therapeutic strategy that involves administering specific biochemical precursors, co-factors, or building blocks that are deficient, allowing the body to naturally synthesize its own required hormones, neurotransmitters, or functional proteins. Unlike traditional hormone replacement, this approach aims to support and restore the body’s endogenous production capacity by supplying the necessary raw materials. It represents a gentler, more physiological method of modulating the endocrine system.