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Substrate Handling

Meaning

Substrate handling refers to the complex and dynamic physiological processes by which the body ingests, digests, absorbs, transports, stores, and ultimately utilizes metabolic substrates, which primarily include carbohydrates, fats, and proteins. This comprehensive process is the core of metabolic health and is exquisitely regulated by a network of key hormones, including insulin, glucagon, and thyroid hormones. Efficient handling is characterized by high metabolic flexibility, allowing for a smooth and rapid shift between different fuel sources based on the body’s current energy needs and activity level.