Skip to main content

Substrate Availability Metrics

Meaning

Substrate availability metrics are a set of quantifiable laboratory and clinical measures used to assess the concentration and accessibility of essential precursor molecules required for critical biochemical synthesis pathways, particularly the production of hormones. These metrics include the levels of cholesterol, specific amino acids, vitamins, and minerals that serve as the fundamental building blocks for steroidogenesis, neurotransmitter synthesis, and thyroid hormone creation. Clinicians utilize these data points to identify potential nutritional bottlenecks that could be limiting the body’s capacity to maintain optimal endocrine function. Ensuring robust substrate availability is a foundational step in personalized hormonal wellness protocols.