What is the Origin of Substance P?

The name 'Substance P' is historical, derived simply because it was the first substance, designated 'P' for powder, to be isolated and characterized as a biologically active component from brain and intestinal extracts. Its identification in the 1930s marked a significant step in understanding the chemical nature of nervous system signaling. Later research confirmed its identity as a member of the tachykinin peptide family. The early, non-descriptive naming reflects its pioneering discovery.

What is the Mechanism of Substance P?

Substance P exerts its biological effects by binding to the neurokinin 1 receptor (NK1R), a G-protein coupled receptor, which is expressed on various cell types, including neurons, immune cells, and endothelial cells. Receptor activation triggers a signal transduction cascade that leads to the depolarization of nociceptive neurons, promoting the sensation of pain. In inflammatory states, its release from nerve endings causes vasodilation and plasma extravasation, contributing to the local inflammatory response. This potent inflammatory action makes it a target for pain therapeutics.

Substance P

Meaning

Substance P is an undecapeptide, an 11-amino acid neuropeptide, that functions primarily as a neurotransmitter and neuromodulator, widely distributed throughout the central and peripheral nervous systems. Clinically, it is best known for its crucial role in the transmission of pain signals (nociception), acting as a potent mediator of inflammation and neurogenic inflammation. Its concentration is often elevated in conditions associated with chronic pain and inflammatory processes. It is a key molecule in the neuro-immune-endocrine axis.

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Substance P

Meaning

Origin

Mechanism

Can Lifestyle Factors like Stress and Sleep Negate the Benefits of Nutritional Support for Hair?

Can Stress Management Protocols Directly Mitigate Androgenic Hair Changes?

Can Lifestyle Factors beyond Diet and Hormones Influence Hair Regrowth Protocols?

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