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Sublingual Peptide Uptake

Meaning

Sublingual Peptide Uptake describes the non-invasive pharmacological process by which therapeutic peptides are absorbed directly into the systemic circulation through the mucous membranes located under the tongue. This route of administration is specifically employed to circumvent the significant enzymatic degradation that peptides typically undergo in the gastrointestinal tract and the metabolic inactivation from the first-pass hepatic clearance. Achieving efficient sublingual uptake is a key goal in peptide formulation science, offering a convenient and effective alternative to injectable administration for patients. The rapid vascularity of the sublingual region facilitates quick systemic entry.