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Subjective Symptom Validation Science

Meaning

Subjective Symptom Validation Science is the rigorous clinical and scientific process of objectively correlating a patient’s self-reported, non-measurable symptoms—such as generalized fatigue, mood fluctuations, or persistent cognitive impairment—with quantifiable, biological biomarkers and physiological data. This critical discipline recognizes that a patient’s subjective experience is a fundamental data point, especially in complex, subtle hormonal and metabolic disorders that may not present with overt pathology. The process provides a scientific foundation for the patient’s lived experience.