What is the Origin of Subfraction Lipid Analysis?

This technique originated in specialized cardiovascular research, where it became clear that the number and type of lipoprotein particles were more predictive of heart disease risk than the total cholesterol concentration. The term "subfraction" highlights the high-resolution, granular detail provided by this testing, a critical advancement over bulk measurements. It is a cornerstone of precision cardiology and metabolic health.

What is the Mechanism of Subfraction Lipid Analysis?

The analysis typically employs advanced separation techniques, such as nuclear magnetic resonance (NMR) spectroscopy or gradient gel electrophoresis, to physically or magnetically separate the different lipoprotein particles. This allows for the precise counting and sizing of the various subclasses. The mechanism of clinical utility lies in identifying patterns, such as a high concentration of small, dense LDL particles, which directly inform the clinician's choice of diet, supplement, or pharmaceutical intervention.

Subfraction Lipid Analysis ∞ Area

Subfraction Lipid Analysis

Meaning

Subfraction Lipid Analysis is an advanced diagnostic procedure that provides a highly detailed, quantitative breakdown of the various subclasses of lipoproteins, including LDL, HDL, and VLDL, based on their size and density. Unlike a standard lipid panel, this analysis identifies the specific, atherogenic (plaque-forming) particle subtypes, such as small dense LDL, which are often missed by conventional testing. This precision data is crucial for accurate cardiovascular risk stratification and targeted metabolic intervention.