Subdermal Pellet Implantation is a clinical procedure involving the insertion of small, compressed hormone pellets, typically bioidentical testosterone or estradiol, into the subcutaneous fat tissue, usually in the hip or buttock area. This method is a long-acting delivery system designed to provide a steady, continuous release of the hormone directly into the bloodstream over several months. The sustained-release profile avoids the peaks and troughs associated with oral or weekly injectable administration, promoting stable serum hormone levels and enhanced patient compliance. It is a precise and effective method for long-term hormone optimization therapy.
Origin
The concept of using subcutaneous implants for hormone delivery dates back to the 1930s, but modern application utilizes sterile, compounded bioidentical hormones for personalized therapy. The origin of the technique is based on the pharmacological principle of zero-order release kinetics, where the drug is released at a constant rate independent of the concentration gradient. This delivery method gained renewed popularity in the personalized medicine space for its physiological consistency.
Mechanism
The mechanism relies on the dissolution of the compressed hormone matrix within the subcutaneous tissue, where the hormone is slowly released into the highly vascularized surrounding area. The rate of release is primarily governed by the pellet’s surface area, density, and the individual’s local blood flow, providing a predictable and stable pharmacokinetic profile. This steady delivery maintains consistent, physiological hormone concentrations, minimizing side effects associated with hormonal fluctuations.
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