What is the Origin of Subcutaneous Pellet Therapy?

This therapeutic delivery system has historical precedent, but its modern application with bioidentical hormones represents a refinement in clinical endocrinology. The term combines the anatomical site of delivery, "Subcutaneous" (under the skin), with the dosage form, "Pellet," to define the specific method.

What is the Mechanism of Subcutaneous Pellet Therapy?

The mechanism relies on the slow, continuous dissolution of the solid hormone pellet by the surrounding interstitial fluid and local blood flow. This process facilitates the passive diffusion of the active hormone into the systemic circulation at a relatively constant rate. Crucially, this non-oral delivery avoids the hepatic first-pass metabolism, which can alter the hormone's structure and increase the production of certain metabolites, thereby promoting stable and more physiologic serum hormone concentrations.

Subcutaneous Pellet Therapy

Meaning

Subcutaneous Pellet Therapy is a specialized, long-acting method of hormone replacement therapy where small, sterile pellets containing compressed bioidentical hormones, such as testosterone or estradiol, are inserted into the fat layer beneath the skin. This clinical procedure provides a continuous, steady release of the hormone directly into the bloodstream over a period of three to six months, effectively bypassing the daily compliance issues and fluctuations associated with other delivery methods. It is a targeted approach for sustained hormonal balance.

Fractured glass symbolizes endocrine dysfunction or hormonal imbalance in menopause or andropause. White crystals represent bioidentical hormones or peptide therapies for testosterone replacement therapy. Pale fern fronds signify reclaimed vitality and cellular repair via hormone optimization and precision dosing.

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