What is the Origin of Subcutaneous Dosing?

The technique is rooted in classical pharmacology and nursing practice, with subcutaneous literally meaning "under the skin" (from Latin sub and cutis). Its application in endocrinology, particularly for peptide and some steroid therapies, is driven by the need to achieve steady-state plasma concentrations and avoid the rapid peaks and troughs associated with less frequent administration routes.

What is the Mechanism of Subcutaneous Dosing?

The fatty tissue beneath the skin is relatively avascular compared to muscle, which results in a slower, more gradual diffusion of the administered compound into the bloodstream. This slower absorption rate provides a smoother pharmacokinetic profile, minimizing the supra-physiological peaks that can lead to receptor down-regulation or adverse effects. The sustained release achieved through subcutaneous dosing is often considered superior for mimicking the body's endogenous pulsatile hormone secretion.

Subcutaneous Dosing ∞ Area

Subcutaneous Dosing

Meaning

Subcutaneous Dosing is a clinical method of administering a therapeutic agent, such as a hormone or peptide, by injecting it directly into the layer of fatty tissue situated just beneath the skin, but above the muscle layer. This route of administration is preferred for compounds requiring slow, sustained absorption into the systemic circulation, often mimicking the body’s natural, continuous hormone release patterns. It is a precise technique that contrasts with oral or intramuscular delivery methods.