What is the Origin of Subcutaneous Delivery Kinetics?

This term is a specialized application of pharmacokinetics, with 'Subcutaneous' referring to the hypodermis layer of tissue beneath the skin. The subcutaneous route is preferred for many injectable hormones and peptides due to its relatively consistent absorption profile. 'Kinetics' refers to the movement and time-course of the drug within the body, a foundational concept in drug delivery science.

What is the Mechanism of Subcutaneous Delivery Kinetics?

The mechanism involves the drug diffusing from the injection site through the interstitial fluid and into the local capillaries, bypassing the gastrointestinal tract and hepatic first-pass metabolism. The rate of absorption is primarily governed by the drug's molecular size, lipophilicity, and the blood flow at the injection site. This route generally offers a slower, more sustained release compared to intravenous administration, leading to smoother plasma concentration curves.

Subcutaneous Delivery Kinetics

Meaning

The study of the rate and extent to which a substance, such as a peptide or hormone, is absorbed into the systemic circulation following injection into the subcutaneous fat layer. Kinetics encompasses the processes of absorption, distribution, metabolism, and excretion (ADME) specific to this route of administration. Understanding these kinetics is critical for determining appropriate dosing frequency and maintaining stable therapeutic concentrations.