What is the Origin of Subcutaneous Absorption?

This concept is rooted in pharmacology and drug delivery science, describing one of the parenteral routes of administration. The term is derived from the Latin "sub," meaning under, and "cutis," meaning skin.

What is the Mechanism of Subcutaneous Absorption?

Once deposited in the subcutaneous space, the compound diffuses slowly through the interstitial fluid and is then absorbed into the dense network of local capillaries and lymphatic vessels. Crucially, this route bypasses the hepatic first-pass metabolism, which would otherwise rapidly degrade certain compounds if they were administered orally. The relatively poor blood flow in the subcutaneous tissue contributes to a slower and more consistent rate of absorption into the bloodstream.

Subcutaneous Absorption

Meaning

Subcutaneous Absorption is the pharmacological process by which a drug or therapeutic compound, such as a hormone or peptide, enters the systemic circulation after being injected or administered into the hypodermis, the fatty layer of tissue situated just beneath the skin. This route of administration is favored for its ease of use, patient self-administration, and the potential for a slow, sustained release profile. It is a key delivery method in various hormonal therapies.