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Subclinical Thyroid Dysfunction

Meaning

Subclinical Thyroid Dysfunction is a state of mild thyroid hormone imbalance characterized by abnormal levels of Thyroid-Stimulating Hormone (TSH) but with circulating free thyroxine (fT4) and free triiodothyronine (fT3) levels that remain within the established laboratory reference range. This condition, which may be subclinical hypothyroidism or hyperthyroidism, often presents with subtle, non-specific symptoms that significantly impact well-being, such as fatigue or mood changes. While not overtly pathological, it represents a compensatory effort by the pituitary gland to maintain peripheral hormone levels. Clinical vigilance and personalized interpretation are necessary for appropriate management.