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Subclinical Physiological Disturbance

Meaning

Subclinical Physiological Disturbance describes a measurable deviation from optimal biological function that has not yet progressed to the point of meeting the diagnostic criteria for a defined clinical disease state. This early-stage imbalance, often involving mild but persistent dysregulation of hormonal axes, metabolic pathways, or immune function, typically precedes the onset of overt symptoms and diagnosable pathology. Identifying these disturbances is a core objective of preventive and longevity medicine, as they represent the earliest actionable window for intervention. It is a state of compromised but not yet failed homeostasis.