Subclinical Inflammation Management is the clinical strategy focused on identifying and mitigating low-grade, chronic systemic inflammation that exists below the threshold of overt clinical symptoms or traditional disease diagnosis. This smoldering, persistent inflammatory state, characterized by elevated markers like high-sensitivity C-Reactive Protein (hs-CRP), is a primary driver of age-related decline and hormonal dysfunction, including insulin resistance and HPA axis dysregulation. Proactive management is fundamental to longevity and metabolic health.
Origin
This term is rooted in modern pathology and longevity medicine, where the concept of “inflammaging” links chronic, low-level inflammation to the aging process. “Subclinical” emphasizes the absence of acute symptoms, requiring advanced diagnostic testing for detection. Management signifies a targeted, preventative approach based on identifying and addressing underlying systemic stressors.
Mechanism
Management targets the root causes of inflammation, which often include gut dysbiosis, chronic psychological stress, and excess visceral adiposity. Interventions involve optimizing the gut microbiome, enhancing omega-3 fatty acid intake, and promoting regular physical activity to reduce adipose-derived pro-inflammatory cytokine release. By dampening the systemic inflammatory cascade, this mechanism restores cellular sensitivity to key hormones like insulin and thyroid hormone, thereby improving metabolic and endocrine function.
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