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Subclinical Hypogonadism

Meaning

Subclinical hypogonadism is an early or mild state of gonadal dysfunction characterized by circulating sex hormone levels, such as testosterone or estradiol, that are technically within the lower end of the conventional laboratory reference range or are only subtly reduced, often accompanied by non-specific symptoms of hormonal deficiency. Clinically, this condition is defined by the presence of suggestive symptoms—including persistent fatigue, mild sexual dysfunction, or mood changes—in the absence of the overt, clear-cut biochemical criteria that define frank hypogonadism. This state represents a crucial area for functional intervention, as it reflects a suboptimal hormonal environment that can significantly compromise quality of life and long-term metabolic health.