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Sub-Therapeutic Dosing Avoidance

Meaning

Sub-Therapeutic Dosing Avoidance is a critical clinical principle emphasizing the necessity of administering hormonal or pharmacological agents at concentrations that are demonstrably sufficient to elicit the desired physiological or therapeutic effect. Doses consistently below this threshold, known as sub-therapeutic doses, are generally ineffective and may paradoxically lead to adverse outcomes, such as incomplete receptor saturation or the creation of unfavorable metabolite ratios. This principle underscores the importance of precise, data-driven titration to achieve and maintain a true therapeutic window for optimal health benefits.