A targeted clinical focus on maintaining the integrity, density, and functional capacity of the body’s foundational physical components, including the musculoskeletal system, connective tissues, and dermal matrix. This preservation strategy is crucial for sustaining mobility, strength, and resilience against age-related frailty and injury. Optimal hormonal status, particularly of anabolic hormones, is a non-negotiable requirement for successful structural preservation across the lifespan.
Origin
This term integrates principles from geriatrics, orthopedics, and endocrinology, recognizing that physical structure is a key determinant of healthspan and independence. The concept moves beyond simple bone density to encompass the entire supportive framework of the body.
Mechanism
The mechanism relies heavily on the anabolic signaling provided by hormones such as testosterone, growth hormone, and insulin-like growth factor 1 (IGF-1), which stimulate protein synthesis and collagen deposition. These signals regulate the balance between bone resorption and formation, as well as the turnover of muscle and connective tissue proteins. By optimizing these hormonal drivers, the body can effectively counter catabolic forces and maintain a robust physical architecture.
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