Structural Proteins are a class of long, fibrous protein molecules that serve primarily to provide mechanical support, strength, and elasticity to cells, tissues, and the entire body framework. Key examples include collagen, elastin, and keratin, which are essential components of the extracellular matrix, skin, bone, and connective tissues. Maintaining the integrity and synthesis of these proteins is fundamental for tissue resilience, physical mobility, and the outward appearance of youth.
Origin
This term is foundational to biochemistry and histology, with “structural” defining the primary role of these proteins in forming the physical architecture of the organism. They contrast with globular proteins, which are generally functional (e.g., enzymes, hormones) rather than architectural.
Mechanism
The mechanism of structural protein function involves their ability to assemble into complex, stable, and often cross-linked supra-molecular fibers or sheets, resisting tensile and compressive forces. Hormones, particularly growth hormone and sex steroids, modulate the expression of genes encoding these proteins and the activity of the enzymes responsible for their post-translational modification and cross-linking. Age-related decline in these hormones leads to reduced synthesis and increased degradation, compromising tissue strength and elasticity.
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