What is the Origin of Structural Neurogenesis?

This is a core concept in modern neuroscience, evolving from the once-held belief that the adult brain could not generate new neurons. Structural emphasizes the creation of new physical cells, and neurogenesis combines the Greek neuron (nerve) and genesis (creation). Research has confirmed this process is highly modifiable by lifestyle and hormonal factors.

What is the Mechanism of Structural Neurogenesis?

The mechanism involves the proliferation of progenitor cells in the subgranular zone of the dentate gyrus, their migration, and their eventual differentiation into mature, integrated neurons. This entire cascade is profoundly influenced by systemic factors, including physical exercise, caloric restriction, and a favorable hormonal milieu. Neurotrophic factors like BDNF and certain hormones, notably estrogen and testosterone, act as potent signaling molecules that promote the survival and integration of these new cells into existing neural circuits.

Structural Neurogenesis ∞ Area

Structural Neurogenesis

Meaning

Structural Neurogenesis refers to the ongoing biological process of generating new functional neurons from neural stem cells within specific regions of the adult brain, primarily the hippocampus. This process is essential for memory formation, emotional regulation, and maintaining the structural integrity and plasticity of the central nervous system. A healthy rate of structural neurogenesis is a key biological indicator of brain vitality and resilience against age-related decline.