Structural Mass Retention is the physiological imperative to maintain or increase lean muscle mass and bone mineral density, processes critically dependent on anabolic signaling mediated by hormones like growth hormone, IGF-1, and androgens. Failure in retention signifies a catabolic state often associated with endocrine decline or chronic inflammation. This is fundamental to physical resilience.
Origin
The concept is derived from the study of sarcopenia and osteoporosis, conditions heavily influenced by the decline in anabolic hormone signaling with age or endocrine disease. Retention strategies are paramount in optimizing long-term physical function.
Mechanism
Retention operates through anabolic pathways that promote protein synthesis over degradation within skeletal muscle fibers and osteoblasts within bone matrix. Adequate levels of testosterone or its metabolites, for instance, directly stimulate muscle protein accretion via the AKT/mTOR pathway. This mechanism requires sufficient substrate availability and responsive receptor populations to counteract age-related catabolic tendencies.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.