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Stromal-Epithelial Interaction

Meaning

Stromal-epithelial interaction describes the essential, dynamic, and reciprocal paracrine communication process that occurs between the epithelial cells, which form the functional lining of organs, and the surrounding stromal cells, which constitute the supportive connective tissue matrix. This molecular dialogue is fundamental for proper organ development, the maintenance of normal tissue homeostasis, and the regenerative capacity of many organs, including the prostate and breast. Dysregulation of this intricate interaction is a common and critical precursor to various pathological conditions.