A class of synthetic or naturally derived short-chain amino acid compounds under investigation for their ability to mitigate neurological damage and accelerate the restoration of function following an acute ischemic or hemorrhagic stroke. These peptides are a focus of regenerative medicine for neurorehabilitation. They offer a targeted molecular approach to improving patient outcomes post-injury.
Origin
This field developed from the intersection of neurobiology and peptide therapeutics, driven by the need for agents that can exploit the brain’s inherent capacity for repair following acute injury. The identification of neurotrophic factors as key mediators of neural repair established the rationale for peptide-based mimetics. This research seeks to expand the therapeutic window beyond acute intervention.
Mechanism
Stroke recovery peptides function by multiple neuroprotective and neurorestorative mechanisms, including reducing the extent of the initial infarct by limiting excitotoxicity and cellular apoptosis. They actively promote angiogenesis, the formation of new blood vessels, and stimulate neurogenesis in the subventricular zone and hippocampus. Furthermore, these compounds modulate the post-stroke inflammatory response, creating a more favorable environment for synaptic reorganization and functional recovery.
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