Question 1

What is the Meaning of Stress Signaling Suppression?

Accepted Answer

Stress Signaling Suppression is the clinical objective of mitigating the excessive or chronic activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and the sympathetic nervous system, thereby reducing the sustained release of catabolic stress hormones, primarily cortisol and catecholamines. This suppression is essential for preventing the detrimental downstream effects of chronic stress, including immune dysregulation, visceral fat accumulation, and suppression of the reproductive axis. The goal is to restore the HPA axis to a state of healthy, rapid responsiveness with efficient negative feedback.

Question 2

What is the Origin of Stress Signaling Suppression?

Accepted Answer

This term is rooted in psychoneuroendocrinology, recognizing that modern life often leads to a pathological state of allostatic overload, where the stress response system is chronically over-activated. The concept of 'suppression' is a therapeutic one, aiming to re-establish the central nervous system's capacity to inhibit the stress cascade once the perceived threat has passed, a process often impaired in chronic stress states.

Question 3

What is the Mechanism of Stress Signaling Suppression?

Accepted Answer

The mechanism involves enhancing the glucocorticoid receptor sensitivity within the hippocampus and hypothalamus, which is the primary site of negative feedback for the HPA axis. Increased receptor sensitivity allows lower levels of circulating cortisol to effectively shut down the release of CRH and ACTH, thereby suppressing the stress cascade. Furthermore, interventions targeting the parasympathetic nervous system promote vagal tone, which acts as a physiological brake on the sympathetic output, reducing the secretion of norepinephrine and epinephrine and facilitating a return to systemic homeostasis.

Stress Signaling Suppression

Meaning

Origin

Mechanism

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