What is the Origin of Stress Response Systems?

This concept is foundational to stress physiology, integrating neurobiology and endocrinology. The understanding of the body's reaction to threat was formalized by Hans Selye's work on the General Adaptation Syndrome. The term "stress" itself, originally a concept from physics referring to pressure, was adopted to describe the non-specific response of the body to any demand for change.

What is the Mechanism of Stress Response Systems?

The HPA axis is activated when the hypothalamus releases CRH, leading to ACTH release from the pituitary, which stimulates the adrenal cortex to secrete cortisol. Simultaneously, the SAM axis rapidly activates the sympathetic nervous system, leading to the adrenal medulla's release of catecholamines like epinephrine and norepinephrine. These two mechanisms work on different timescales—SAM is rapid, HPA is sustained—to mobilize energy, heighten vigilance, and suppress non-essential functions like digestion and reproduction.

Stress Response Systems

Meaning

Stress Response Systems comprise the interconnected physiological and neuroendocrine pathways that the body utilizes to perceive, interpret, and adapt to internal or external challenges, known as stressors. The two primary axes are the Hypothalamic-Pituitary-Adrenal (HPA) axis and the Sympathetic-Adrenal-Medullary (SAM) axis, which together orchestrate the fight-or-flight response. The proper function and rapid recovery of these systems are essential for maintaining allostatic balance and hormonal health.

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How Do Wellness Program Rewards Impact Long-Term Health Outcomes?

Wellness rewards shape long-term health by recalibrating the body's hormonal and neurochemical feedback loops for sustained motivation.

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HRTioSeptember 28, 2025

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HRTioAugust 28, 2025

Stress Response Systems

Meaning

Origin

Mechanism

How Do Wellness Program Rewards Impact Long-Term Health Outcomes?

How Do Courts Define Coercion in Workplace Wellness Programs?

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