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Stress Response Pathway Modulation

Meaning

Stress Response Pathway Modulation describes the clinical process of selectively influencing the activity of the body’s primary stress axes, particularly the Hypothalamic-Pituitary-Adrenal (HPA) axis and the sympathetic nervous system. The goal of modulation is not to eliminate the stress response entirely but to restore its appropriate magnitude and timely termination, thereby enhancing resilience and preventing chronic maladaptation. Effective modulation is crucial for maintaining hormonal balance, reducing allostatic load, and protecting against the long-term metabolic and immune consequences of chronic stress.