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Stress Resilience Signaling

Meaning

The efficiency and robustness of the neuroendocrine and cellular pathways that allow an organism to precisely sense, appropriately respond to, and fully recover from various physiological and psychological stressors while maintaining core homeostatic balance. High resilience signaling is characterized by a rapid, appropriate activation of the stress response followed by an equally swift and complete deactivation. This critical capacity prevents the cumulative burden of allostatic load, which is a major contributor to age-related chronic disease.