A composite, clinically derived metric that quantifies an individual’s physiological and psychological capacity to effectively manage and recover from acute and chronic stressors. This index is typically calculated by assessing key hormonal biomarkers, such as the diurnal cortisol curve and DHEA-S levels, alongside heart rate variability (HRV) and subjective psychological data. A low index indicates depleted adrenal reserves and a heightened state of allostatic load, correlating with increased vulnerability to illness and burnout. The index provides an objective measure of the body’s adaptive reserve.
Origin
This concept originates from psychoneuroendocrinology and the study of allostasis, the process of achieving stability through physiological change. The term ‘Index’ reflects a move toward quantifiable clinical assessment of a complex adaptive trait. The scientific basis lies in the detailed understanding of the Hypothalamic-Pituitary-Adrenal (HPA) axis and its role in mediating the body’s response to perceived threat.
Mechanism
Resilience is primarily mediated by the HPA axis, which controls the release of glucocorticoids like cortisol, essential for mobilizing energy and modulating immune response during stress. The index measures the efficiency of this axis, specifically its ability to activate appropriately and then return to baseline quickly. Optimal hormonal balance, particularly the cortisol-DHEA ratio, is crucial for maintaining the adaptive capacity of the stress response system without incurring chronic damage.
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