Stress Resilience Chemistry describes the specific constellation of endogenous biochemical factors that enable an organism to rapidly adapt to and recover from acute physiological or psychological stressors. This involves the optimal function of the HPA axis, robust antioxidant capacity, and appropriate neurochemical buffering systems. It quantifies the body’s innate ability to handle challenge.
Origin
Rooted in psychoneuroendocrinology, this term focuses on the molecular underpinnings of adaptation. Resilience refers to the inherent robustness of the system, determined by the chemical milieu available to respond to the stressor event.
Mechanism
The mechanism relies on the swift, proportional release of adrenal hormones followed by rapid negative feedback and clearance to prevent prolonged tissue exposure. Key components include the balance between cortisol and DHEA-S, and the availability of substrates necessary for rapid ATP regeneration. Enhanced resilience chemistry ensures that the adaptive response is sufficient but not excessive.
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